Local toxicity of benzalkonium chloride in ophthalmic solutions following repeated applications
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چکیده
منابع مشابه
MICROBIOLOGICAL EVALUATION OF SOME OPHTHALMIC PREPARATIONS CONTAINING DIFFERENT CONCENTRATIONS OF BENZALKONIUM CHLORIDE
Zinc sulphate and boric acid ophthalmic preparations, containing benzalkonium chloride as preservative, have been investigated against gram-negative and positive bacteria. Viability of bacteria was found after 7 days, although it was completely suppressed after 24 hours of inoculation. Zinc sulphate generally increases the antimicrobial activity of benzalkonium chloride, whereas boric acid ...
متن کاملOcular Toxicity of Benzalkonium Chloride Homologs Compared with Their Mixtures
This study was performed to assess the in vivo ocular toxicity of benzalkonium chloride (BAK) homologs compared with commercially available BAK (BAK mixture) and to assess the ocular toxicity of BAK homolog after repeated ocular application. Rabbit eyes were examined by ophthalmology and scanning electron microscopy (SEM) after 10 applications of BAK homologs with C12 (C12-BAK) and C14 (C14-BAK...
متن کاملDetermination of Benzalkonium Chloride in Ophthalmic Solutions by Stability-Indicating HPLC Method: Application to a Stability Study
Article history: Received on: 29/02/2016 Revised on: 15/03/2016 Accepted on: 06/04/2016 Available online: 28/05/2016 A simple HPLC method for determination of Benzalkonium chloride in various ophthalmic solutions was developed. The chromatographic analysis was achieved using CN column (250 mm, 4.6 mm i.d., 5 μm) with isocratic mobile phase consisting of acetonitrile phosphate buffer (pH 5.5; 0....
متن کاملCytotoxicity of five fluoroquinolone and two nonsteroidal anti-inflammatory benzalkonium chloride-free ophthalmic solutions in four corneoconjunctival cell lines
PURPOSE Epithelial disorders after eye surgery can result in visual deterioration and patient discomfort. Such disorders may be caused by drug toxicity. In the present study, we evaluated the toxicity of ophthalmic solutions, with or without benzalkonium chloride (BAK) as the preservative, used for postoperative care. METHODS A range of commercially available antibiotic and anti-inflammatory ...
متن کاملEvaluation of the cytotoxic effects of ophthalmic solutions containing benzalkonium chloride on corneal epithelium using an organotypic 3-D model
BACKGROUND Benzalkonium chloride (BAC) is a common preservative used in ophthalmic solutions. The aim of this study was to compare the cytotoxic effects of BAC-containing ophthalmic solutions with a BAC-free ophthalmic solution using an organotypic 3-dimensional (3-D) corneal epithelial model and to determine the effects of latanoprost ophthalmic solution and its BAC-containing vehicle on corne...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2013
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.38.531